Rabbit Polyclonal antibody to ERABFunctions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
Immunogen
Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
17b-HSD10 ABAD CAMR DUPXp11.22 ERAB HADH2 HCD2 MHBD MRPP2 MRX17 MRX31 MRXS10 SCHAD SDR5C1 HSD17B10 endoplasmic reticulum-associated amyloid beta-peptide-binding protein short chain type dehydrogenase/reductase XH98G2 AB-binding alcohol deh
Target
ERAB
Molecular Weight(MW)
27 (note)
Application
Application
Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Antibody
Application Notes
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.