Rabbit polyclonal to F1A alphaFas and Tumor Necrosis Factor Receptor 1 (TNFR 1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR 1 was recently identified and designatedF1A alpha and FEM 1 beta. F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM 1. FEM 1/F1Aa is cleaved by CED-3 and caspase. FEM 1/F1Aa associates with CED-4 and its mammalian homologue Apaf 1. Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues.
Immunogen
Synthetic peptide: amino acids 609-622 of Human F1A alpha. This sequence is identical to the corresponding sequence of mouse.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
For WB: Use at a dilution of 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the researcher.:
Species Reactivity
HumanMouseRat
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
Q9UK73 F1A alpha FEM1B FIAA 10116
Target
F1A alpha
Application
Application
Application
Application
Immunohistochemical staining of F1Aα in mouse liver tissue with F1Aα antibody at 5ug/ml.
Positive Control
Mouse liver tissue lysate
Application Notes
For WB: Use at a dilution of 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the researcher.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.