| Product Name | Factor B (Bb fragment) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [032B-22.1.X] to Factor B (Bb fragment)This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008] |
| Immunogen | Purified human factor B |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 032B-22.1.X |
| Host Species | Mouse |
| Tested Applications | ELISAFACSWB |
| FACS:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AHUS4 FBI12 FB CFAB BFD BF CFB GBG H2-BF PBF2 |
|---|---|
| Target | Complement Factor Bb NeoAntigen |
| Tissue Specificity | This antibody recognizes a neoantigen of the Bb fragment of human complement factor B. |
| Application Notes | FACS:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Borate buffered saline containing 0.09% Sodium Azide (NaN3) |
