| Product Name | Fibrinogen antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [15E11] to FibrinogenFibrinogen is the main protein of blood coagulation system. It is a large protein (MW 340 kDa) and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. |
| Immunogen | Fibrin degradation products |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| ELISA: Use at an assay dependent dilution. (capture, detection). WB: Use at an assay dependent dilution. Use under non-reducing conditions. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | FGA 134830 2271 MGC119423 MGC120405 MGC104327 105200 P02675 FH Fibrinogen MCUL1 136850 P07954 MGC119425 2244 2243 Fib2 FGB P02671 HLRCC MCL MGC119422 LRCC |
|---|---|
| Target | Fibrinogen |
| Tissue Specificity | Fibrinogen, Fibrin degradation products. |
| Application Notes | ELISA: Use at an assay dependent dilution. (capture, detection). WB: Use at an assay dependent dilution. Use under non-reducing conditions. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4 |
