Rabbit polyclonal antibody to FKBP12FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIPWB
Western blot (0.5-4 µg/ml), immunoprecipitation (2-10 µg/ml) and Immunohistochemistry (2-10 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 12 kDa FKBP12 protein in samples from human, mouse, and rat origins.:
Species Reactivity
HumanMouseRat
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
FKBP1A FKBP1 FKBP12
Target
FKBP12
Tissue Specificity
This antibody is specific for FKBP12.
Application
Application
Western blot analysis of FKBP12 expression in rat kidney tissue lysate.
Application Notes
Western blot (0.5-4 µg/ml), immunoprecipitation (2-10 µg/ml) and Immunohistochemistry (2-10 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 12 kDa FKBP12 protein in samples from human, mouse, and rat origins.:
Additional Information
Form
Liquid
Storage Instructions
The antibody solution should be gently mixed before use. Stored at -20 °C for future use.