| Product Name | GITR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7R12] to GITRThis gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Immunogen | Human recombinant TNFRSF18 EC domain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 7R12 |
| Host Species | Mouse |
| Tested Applications | FACSNeutWB |
| WB(1:500-1000)|Neutralization of Ligand/receptor interaction|FC(1:50-200): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AITR GITR tumor necrosis factor receptor superfamily member 18 CD357 GITR-D |
|---|---|
| Target | TNFRSF18 |
| Tissue Specificity | This antibody was selected for its ability to detect human GITR |
| Application Notes | WB(1:500-1000)|Neutralization of Ligand/receptor interaction|FC(1:50-200): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
