| Product Name | HMW Kininogen antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [2B5] to HMW KininogenThis gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Purified high molecular weight kininogen (HMWK). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2B5 |
| Host Species | Mouse |
| Tested Applications | ELISANeutWB |
| Dilute in PBS or medium which is identical to that used in the assay system. This antibody can neutralize the inhibitory activity of HMWK on platelet calpain. This antibody can also be used for coagulation studies.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Synonyms | KNG BDK HMW Kininogen |
|---|---|
| Target | HMW Kininogen |
| Tissue Specificity | This antibody reacts with the common heavy chain (mw~46,000) of human HMWK. |
| Application Notes | Dilute in PBS or medium which is identical to that used in the assay system. This antibody can neutralize the inhibitory activity of HMWK on platelet calpain. This antibody can also be used for coagulation studies.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS, pH7.2 |
Data sheet for OM257236