| Product Name | hnRNP Q antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [I8E4] to hnRNP QSpinal muscular atrophy (SMA) is a common neurodegenerative disease caused by deletion or loss-of-function mutations of the survival of motor neurons (SMN) protein. SMN is complexed with several proteins, including Gemin2, Gemin3 and Gemin4, and plays important roles in small nuclear ribonucleoprotein (snRNP) biogenesis and in pre-mRNA splicing. The hnRNP Q proteins interact with SMN, they are required for efficient pre-mRNA splicing in vitro. The hnRNP Q proteins may provide a molecular link between the SMN complex and splicing. |
| Immunogen | Recombinant untagged hnRNP Q protein (human) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | I8E4 |
| Host Species | Mouse |
| Tested Applications | ELISAICC/IFIPWB |
| Optimal dilutions should be determined experimentally by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | FLJ31626 GRY-RBP GRYRBP HNRPQ1 NSAP1 PP68 dJ3J17.2 hnRNP-Q GRY RBP hnRNP Q hnRNPQ |
|---|---|
| Target | hnRNP Q |
| Tissue Specificity | Human hnRNP-Q. Detects a band of approximately 55, 60, 70 kDa (Q1-Q3). It cross reacts with mouse & xenopus |
| Cellular Localization | The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed predominantly in the nucleoplasm. Expressed predominantly in the nucleoplasm. Expressed p |
| Application Notes | Optimal dilutions should be determined experimentally by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS + 0.1% sodium azide |
