| Product Name | IGF1R antibody [alphaIR3] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [alphaIR3] to IGF1 ReceptorThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| Immunogen | Immunogen used was partially purified receptor from human placenta. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | alphaIR3 |
| Host Species | Mouse |
| Tested Applications | ICC/IFIPNeut |
| For IF: Use at a concentration of 1 - 5 μg/ml. For IP: Use at an assay dependent dilution. For Neut: Use at a concentration of 1 μg/ml. Not suitable for use in IHC-P or WB. Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CD221 antibody, IGF1 receptor antibody, IGF1 receptor antibody, IGF1A antibody, IGF1R antibody, IGFI antibody, IGFI antibody, IGFIR antibody, IGFIRC antibody, IGFR antibody, Insulin like growth factor1 receptor antibody, Insulin like growth fact |
|---|---|
| Target | IGF1 receptor |
| Tissue Specificity | Recognizes the human IGF-I Receptor. IGF-I Receptor (Ab-1) immunoprecipitates the a and ? subunits of the IGF-I receptor. IGF-I receptor () blocks IGF-I binding to its receptor and may bind weakly to the insulin receptor. It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth. |
| Cellular Localization | Plasma membrane |
| Application Notes | For IF: Use at a concentration of 1 - 5 μg/ml. For IP: Use at an assay dependent dilution. For Neut: Use at a concentration of 1 μg/ml. Not suitable for use in IHC-P or WB. Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | 0.05 M sodium phosphate buffer, 0.2% gelatin, and =0.1% sodium azide. |
