| Product Name | IL10 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [6Q24] to IL10The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] |
| Immunogen | Human recombinant IL-10 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 6Q24 |
| Host Species | Mouse |
| Tested Applications | NeutWB |
| WB(1:500-2000)|Neutralization of IL-10 bioactivity: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CSIF IL10A interleukin 10 IL10 TGIF GVHDS |
|---|---|
| Target | IL10 |
| Tissue Specificity | This antibody was selected for its ability to detect human IL-10. |
| Application Notes | WB(1:500-2000)|Neutralization of IL-10 bioactivity: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
