| Product Name | IL12B / IL12 p40 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [2S25] to IL-12 p40This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |
| Immunogen | The immunogen corresponding to a region within amino acids 23 and 328 of Human IL-12 p40 (Uniprot: P29460) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 2S25 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| WB(1:100-500)|ELISA(1:1000-2000): |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | IL12B IL-12B NKSF2 interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40) CLMF2 NKSF CLMF |
|---|---|
| Target | IL-12 p40 |
| Tissue Specificity | This antibody recognizes human IL-12 p40 heterodimers and dimers in western blot and Elisa |
| Application Notes | WB(1:100-500)|ELISA(1:1000-2000): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
