| Product Name | Integrin alpha 2b + beta 3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [290.5C10] to Integrin alpha 2b + beta 3The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation. |
| Immunogen | Integrin beta 3 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 290.5C10 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSIHC-PIPWB |
| For ELISA: Use at an assay dependent dilution. For FACS, IHC-P, IP and WB: Use at a dilution of 1:50 - 1:100. Detects a band of approximately 95 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Integrin alpha2b + beta3 CD61 Integrin beta 3 Integrin alpha2b Integrin beta3 Integrin alpha 2b GPIIIa CD41b Integrin alpha 2b + beta3 Integrin alpha 2b + beta 3 GPIIIb CD41 GP3A GP2B GPIIb GTA HPA3 |
|---|---|
| Target | Integrin alpha 2b + beta 3 |
| Tissue Specificity | Reacts with human beta3 integrin chain. Cross-reacts with avbeta3 and allbbeta3 integrin chains. |
| Cellular Localization | Cell Membrane |
| Application Notes | For ELISA: Use at an assay dependent dilution. For FACS, IHC-P, IP and WB: Use at a dilution of 1:50 - 1:100. Detects a band of approximately 95 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | No preservatives added |
