| Product Name | IRAK2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to IRAK2The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB (1), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (2). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation (3,4). Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues. |
| Immunogen | Synthetic peptide, corresponding to amino acids 571-590 of Human IRAK2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blot at 1:500 to 1:1000 dilution and a65 kDa band can be detected.: |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Gene Synonyms | IRAK-2 MGC150550 IRAK 2 IRAK2 |
|---|---|
| Target | IRAK2 |
| Tissue Specificity | Anti-IRAK2 has no crossresponse to IRAK. |
| Positive Control | K562whole cell lysate |
|---|---|
| Application Notes | Western blot at 1:500 to 1:1000 dilution and a65 kDa band can be detected.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide |
