| Product Name | Mc5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [131-11741(P3/NS1/1-Ag4-1)] to Mc5The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 131-11741(P3/NS1/1-Ag4-1) |
| Host Species | Mouse |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD227 EMA H23AG MAM6 PEM PEMT PUM mucin |
|---|---|
| Target | Mc5 |
| Tissue Specificity | Epithelial Mucin Antigen (Mc5) |
| Cellular Localization | Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions. On EGF and PDGFRB |
| Light Chain Type | kappa |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt, store at –20°C. Avoid multiple freeze/thaw cycles. |
| Storage Buffer | 10 mM Sodium Phosphate, pH 7.4 containing 150 mM Sodium Chloride and 0.1% Sodium Azide |
