| Product Name | MLL1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to MLL1This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blotting (1:500 – 1:2000). However, the optimal concentrations should be determined individually. K562 nuclear extract can be used as a positive control. The antibody recognizes the MLL1 of human and mouse origins. Reactivity to other species has not been tested.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | TRX1 HRX HGNC:7132 CXXC7 myeloid/lymphoid or mixedlineage leukemia MLL ALL1 HTRX1 MLL1 human trithorax 1 acute lymphocytic leukemia 1 ALL-1 acute lymphocytic leukemia1 myeloid/lymphoid or mixed-lineage leukemia human trithorax1 ALL 1 |
|---|---|
| Target | MLL1 |
| Tissue Specificity | This antibody is specific for MLL1. |
| Cellular Localization | Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. |
| Application Notes | Western blotting (1:500 – 1:2000). However, the optimal concentrations should be determined individually. K562 nuclear extract can be used as a positive control. The antibody recognizes the MLL1 of human and mouse origins. Reactivity to other species has not been tested.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal |
