Application
Western blot analysis of Nav1.8 in COS transient cells using a 1:1000 dilution ofApplication
IHC analysis of Nav1.8 in mouse back skin sections using a dilution of| Product Name | NAV1.8 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [S134-12] to NAV1.8This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta regulatory auxiliary subunits (in vitro). Plays a role in neuropathic pain mechanisms. |
| Immunogen | Fusion protein amino acids 1724-1956 of rat Nav1.8, accession number Q62968 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | S134-12 |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHCWB |
| We recommend a working dilution of 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF).: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | Na(V)1.8 PN3 Scn10a |
|---|---|
| Target | NAV1.8 |
| Molecular Weight(MW) | 220kDa (note) |
| Tissue Specificity | No cross reactivity against other Nav channels |
| Cellular Localization | It can be translocated to the extracellular membrane through association with S100A10. |
Application
Western blot analysis of Nav1.8 in COS transient cells using a 1:1000 dilution of
Application
IHC analysis of Nav1.8 in mouse back skin sections using a dilution of| Application Notes | We recommend a working dilution of 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS pH7.4, 50% glycerol |
