| Product Name | P Glycoprotein antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [UIC2] to P GlycoproteinThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | UIC2 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIHC-FIHC-PIP |
| Immunohistology - Paraffin: Max Dilution 1/200 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanPrimate |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | ABCB1 PGY1 GP170 ABC20 CD243 P-GP ATP-binding cassette sub-family B (MDR/TAP) member 1 MDR1 CLCS |
|---|---|
| Target | P Glycoprotein |
| Tissue Specificity | This antibody recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein). |
| Application Notes | Immunohistology - Paraffin: Max Dilution 1/200 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) |
