Mouse monoclonal antibody [2D4] to PAX8Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition cha
Immunogen
The immunogen corresponding to human PAX8 expressed in E. Coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2D4
Host Species
Mouse
Tested Applications
ELISAWB
ELISA: 1/10000.:
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
B-ALPHA-1 TUBA3 LIS3 TUBA1A
Target
PAX8
Molecular Weight(MW)
60 kDa (note)
Application
Application
Western blot analysis using PAX8 mouse mAb against Hela (1), HEK293 (2) and Raji (3) cell lysate.
Application Notes
ELISA: 1/10000.:
Additional Information
Form
Liquid
Storage Instructions
Store at 4℃, for long term storage, store at -20℃.