| Product Name | Presenilin 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to Presenilin 1Beta Amyloid peptide (40-42) has been implicated in the pathogenesis of Alzheimeris disease. The generation of beta Amyloid from Amyloid Precursor Protein involves beta- and gamma- secretases. Recent evidence suggests that presenilins are part of a large gamma secretase complex and they may form the catalytic component of the proteolytic activity. The presenilin proteins are multi transmembrane spanning proteins and are predominantly found in the ER and early Golgi. The presenilin proteins also seem to have a sigificant role in the processing of the Notch receptor, which is critical for cell-fate determination during embryogenesis. |
| Immunogen | Synthetic peptide: TELPAPLSYFNRKC (Human) conjugated to KLH. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Rabbit |
| Tested Applications | IPWB |
| IP: Use at a dilution of 1/1000. WB: Use at a dilution of 1/1000 - 1/5000. Predicted molecular weight: 53 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseMonkeyRatBovine |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AD3 FAD PS1 S182 |
|---|---|
| Target | Presenilin 1 |
| Cellular Localization | Integral membrane protein. Golgi and endoplasmic reticulum. Bound to Notch1 which is also at the cell surface. |
| Application Notes | IP: Use at a dilution of 1/1000. WB: Use at a dilution of 1/1000 - 1/5000. Predicted molecular weight: 53 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: none; Constituents: Whole Serum (sterile filtered) |
