Application
Antibody used in WB on Mouse Brain Membranes at 1:4000.Application
Antibody used in WB on Human heart at 0.2-1 ug/ml.| Product Name | AGTR1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AGTR1, AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1R, AT1AR, AT1BR |
| Product description | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.1) Kurland, L., (2008) Am. J. Hypertens. 21 (7), 836-839. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AGTR1. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| AGTR1 antibody can be used for detection of AGTR1 by ELISA at 1:62500. AGTR1 antibody can be used for detection of AGTR1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
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| Species Reactivity | DogHumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | AGTR1 |
|---|---|
| Alternative Names | AGTR1 AG2S AGTR1A AGTR1B AT1 AT1B AT2R1 AT2R1A AT2R1B HAT1R AT1R AT1AR AT1BR |
| Molecular Weight(MW) | 41 kDa |
Application
Antibody used in WB on Mouse Brain Membranes at 1:4000.
Application
Antibody used in WB on Human heart at 0.2-1 ug/ml.| Positive Control | 1) Cat. No. XBL-10407 - Fetal Heart Tissue Lysate |
|---|---|
| Application Notes | AGTR1 antibody can be used for detection of AGTR1 by ELISA at 1:62500. AGTR1 antibody can be used for detection of AGTR1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store AGTR1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
