Application
Immunohistochemistry staining of APAF1 in liver tissue using APAF1 Antibody.Application
Immunohistochemistry staining of APAF1 in heart using APAF1 Antibody.| Product Name | APAF1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APAF1, APAF-1, CED4, KIAA0413 |
| Product description | Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer. |
| Immunogen | APAF1 antibody was raised against amino acids 12-28 of APAF1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| APAF1 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 2.5 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Gene Symbol | APAF1 |
|---|---|
| Alternative Names | APAF1 APAF-1 CED4 KIAA0413 |
Application
Immunohistochemistry staining of APAF1 in liver tissue using APAF1 Antibody.
Application
Immunohistochemistry staining of APAF1 in heart using APAF1 Antibody.| Application Notes | APAF1 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 2.5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store APAF1 antibody at 4 ˚C, Avoid Freezing |
| Storage Buffer | PBS, 0.02% sodium azide. |
