Application
Immunohistochemistry staining of BIRC2 in prostate tissue using BIRC2 Antibody.| Product Name | BIRC2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. c-IAP1 and c-IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) family originally identified in baculoviruses. Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-a by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP. |
| Immunogen | BIRC2 antibody was raised against a synthetic peptide corresponding to 361 - 372 of BIRC2 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| BIRC2 antibody can be used in immunohistochemistry starting at 10 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BIRC2 |
|---|---|
| Alternative Names | BIRC2 API1 C-IAP1 CIAP1 Hiap-2 IAP homolog B HIAP2 IAP-2 RNF48 Apoptosis inhibitor 1 IAP2 MIHB RING finger protein 48 |
Application
Immunohistochemistry staining of BIRC2 in prostate tissue using BIRC2 Antibody.| Application Notes | BIRC2 antibody can be used in immunohistochemistry starting at 10 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | BIRC2 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | Neat serum, 0.05% sodium azide. |
