Application
Immunohistochemistry of Bonzo in human spleen tissue with Bonzo antibody at 20 μg/mL.Application
Immunofluorescence of Bonzo in human spleen tissue with Bonzo antibody at 20 μg/ml.Application
Immunohistochemistry of Bonzo in human spleen tissue with Bonzo antibody at 2.5 μg/ml.Application
Western blot analysis of Bonzo in human spleen tissue lysate with Bonzo antibody at 1 μg/mL in (A) the absence or (B) the presence of blocking peptide.| Product Name | Bonzo Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Bonzo Antibody: BONZO, CD186, STRL33, TYMSTR, BONZO, C-X-C chemokine receptor type 6, CDw186, CXC-R6 |
| Product description | Bonzo Antibody: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.1) Deng HK, Unutmaz D, KewalRamani VN, et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997; 388:296-300. |
| Immunogen | Bonzo antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bonzo/STRL33. The immunogen is located within the first 50 amino acids of Bonzo. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| Bonzo antibody can be used for detection of Bonzo by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CXCR6 |
|---|---|
| Alternative Names | Bonzo Antibody: BONZO CD186 STRL33 TYMSTR BONZO C-X-C chemokine receptor type 6 CDw186 CXC-R6 |
| Molecular Weight(MW) | Predicted: 38 kDa Observed: 43 kDa |
| Sequence Similarities | 2) Cat. No. 10-901 - Human Spleen Tissue Slide |
Application
Immunohistochemistry of Bonzo in human spleen tissue with Bonzo antibody at 20 μg/mL.
Application
Immunofluorescence of Bonzo in human spleen tissue with Bonzo antibody at 20 μg/ml.
Application
Immunohistochemistry of Bonzo in human spleen tissue with Bonzo antibody at 2.5 μg/ml.
Application
Western blot analysis of Bonzo in human spleen tissue lysate with Bonzo antibody at 1 μg/mL in (A) the absence or (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
|---|---|
| Application Notes | Bonzo antibody can be used for detection of Bonzo by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Bonzo antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Bonzo Antibody is supplied in PBS containing 0.02% sodium azide. |
