| Product Name | FLIP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes. |
| Immunogen | Recombinant human FLIP (aa 1-480). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICCIHCWB |
| Immunohistochemistry (paraffin sections) . Western Blot (1:1000). | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | CFLAR |
|---|---|
| Alternative Names | I-FLICE CLARP CASPER Usurpin CASH FLAME-1 |
| Tissue Specificity | Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. |
| Application Notes | Immunohistochemistry (paraffin sections) . Western Blot (1:1000). |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
