Application
Immunohistochemistry staining of GRM5 in colon, myenteric plexus tissue using GRM5 Antibody.| Product Name | GRM5 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRM5, GPRC1E, MGLUR5, Mglur5b, MGlu5 |
| Product description | Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia |
| Immunogen | GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.: |
|
| Species Reactivity | BatBovineChickenDogGibbonHamsterHorseHumanMonkeyMousePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GRM5 |
|---|---|
| Alternative Names | GRM5 GPRC1E MGLUR5 Mglur5b MGlu5 |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of GRM5 in colon, myenteric plexus tissue using GRM5 Antibody.| Application Notes | GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | GRM5 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
