Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degradation. This antibody should be useful for the localization of granzyme B-containing lytic granules and for the characterization of activated CTLs or NK cells.
Immunogen
GZMB antibody was raised against amino acids from the C-Terminus of Granzyme B (Human)
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
IHC
GZMB antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 10 μg/mL.: