Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R (Ab-1346).Application
Western blot analysis of lysed extracts from 293 cells using IGF-1R (Ab-1346).| Product Name | IGF 1R Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IGFR, CD221, IGFIR, JTK13, BHLHA38, TWIST, Insulin-like growth factor I receptor, IGF1R, kinase IGF1R |
| Product description | This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.1) Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1): 427-35 |
| Immunogen | IGF-1R (Ab-1346) antibody was raised against a peptide sequence around aa.1344~1348 (Q-P-Y-A-H) derived from Human IGF-1R . |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IGF1R |
|---|---|
| Alternative Names | IGFR CD221 IGFIR JTK13 BHLHA38 TWIST Insulin-like growth factor I receptor IGF1R kinase IGF1R |
| Molecular Weight(MW) | 200, 95 kDa |
| Tissue Specificity | This antibody detects endogenous level of total IGF-1R protein. |
| Entrez Gene | 3480 |
|---|---|
| Protein Accession | NP_000866.1 |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R (Ab-1346).
Application
Western blot analysis of lysed extracts from 293 cells using IGF-1R (Ab-1346).| Application Notes | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
