Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | IGF1R (phospho Tyr1346) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD221, kinase IGF1R, IGF1R |
| Product description | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.1) Ullrich A., EMBO J. 5:2503-2512(1986). |
| Immunogen | IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p)-A-H) derived from Human IGF1R . |
| Modification | p-Tyr1346 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IGF1R |
|---|---|
| Alternative Names | CD221 kinase IGF1R IGF1R |
| Molecular Weight(MW) | 154 kDa |
| Tissue Specificity | The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346. |
| Entrez Gene | 3480 |
|---|---|
| Protein Accession | NP_000866.1 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
