Application
Immunohistochemistry staining of IRAK1 in brain cortex tissue using IRAK1 Antibody.| Product Name | IRAK1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | IRAK (Interleukin-1 receptor-associated kinase 1). Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/ threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4). |
| Immunogen | IRAK1 antibody was raised against amino acids 104 - 117 of IRAK1 (Human) near the carboxy terminus. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIPWB |
| IRAK1 antibody can be used in immunohistochemistry starting at 10 μg/mL, immunoprecipitation, and flow cytometry. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Gene Symbol | IRAK1 |
|---|---|
| Alternative Names | IRAK1 IRAK-1 Pelle Il1rak IRAK Pelle homolog |
Application
Immunohistochemistry staining of IRAK1 in brain cortex tissue using IRAK1 Antibody.| Application Notes | IRAK1 antibody can be used in immunohistochemistry starting at 10 μg/mL, immunoprecipitation, and flow cytometry. |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store IRAK1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
