MAP3K7IP2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of NF.:B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF.:B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.1) Kanayama, A., et al., , (2004) Mol. Cell 15 (4), 535-548.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAP3K7IP2.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
MAP3K7IP2 antibody can be used for detection of MAP3K7IP2 by ELISA at 1:312500. MAP3K7IP2 antibody can be used for detection of MAP3K7IP2 by western blot at 2.0/mL.:
Antibody used in WB on Human HepG2 cells at 0.2-1 ug/ml.
Application
Antibody used in IHC on Human Spermatophore.
Application
Antibody used in IHC on Human Stomach.
Positive Control
1) Cat. No. 1211 - HepG2 Cell Lysate
Application Notes
MAP3K7IP2 antibody can be used for detection of MAP3K7IP2 by ELISA at 1:312500. MAP3K7IP2 antibody can be used for detection of MAP3K7IP2 by western blot at 2.0/mL.:
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store MAP3K7IP2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.