Application
Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.| Product Name | TAB2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TAB2 Antibody: CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2 |
| Product description | TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.1) Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 2000; 5:649-58. |
| Immunogen | TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-P |
| TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TAB2 |
|---|---|
| Alternative Names | TAB2 Antibody: CHTD2 MAP3K7IP2 KIAA0733 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 TAB-2 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Rat: (86%), Mouse: (79%) |
| Tissue Specificity | TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins. |
Application
Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 10-301 - Human Brain Tissue Slide |
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| Application Notes | TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TAB2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TAB2 Antibody is supplied in PBS containing 0.02% sodium azide. |
