Application
Immunohistochemistry staining of MCL1 in spleen tissue using MCL1 monoclonal Antibody.| Product Name | MCL1 Antibody [8C6, 8C6D4B1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death. |
| Immunogen | MCL1 monoclonal antibody was raised against Ni-NTA purified recombinant protein MCL-1 expressed in E. Coli strain M15 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAIHCWB |
| MCL1 antibody can be used in ELISA, immunofluorescence, and immunohistochemistry starting at 0.31 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | MCL1 |
|---|---|
| Alternative Names | MCL1 BCL2L3 Bcl-2-like protein 3 Bcl-2-related protein EAT/mcl1 Bcl2-L-3 MCL1S MCL1L Myeloid cell leukemia ES MCL 1 MCL1-ES TM EAT Mcl-1 |
Application
Immunohistochemistry staining of MCL1 in spleen tissue using MCL1 monoclonal Antibody.| Application Notes | MCL1 antibody can be used in ELISA, immunofluorescence, and immunohistochemistry starting at 0.31 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store MCL1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.4, 0.03% sodium azide. |
