| Product Name | NS3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Nonstructural Protein 3 |
| Product description | The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs. |
| Immunogen | Recombinant hepatitis C virus (HCV) NS3 serine protease domain. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICCWB |
| Immunocytochemistry: (paraformaldehyde fixation) (1:50). Western Blot: (1:500).: |
|
| Species Reactivity | Hepatitis C Virus |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | N/A |
|---|---|
| Alternative Names | Nonstructural Protein 3 |
| Tissue Specificity | Recognizes HCV NS3 (genotype 1a and 1b) (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex. Does not cross-react with HCV NS3 (genotype 2a). t |
| Application Notes | Immunocytochemistry: (paraformaldehyde fixation) (1:50). Western Blot: (1:500).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
