| Product Name | NS5B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Nonstructural Protein 5B |
| Product description | The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs. |
| Immunogen | Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (genotype 1a). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WB |
| Western Blot: (1:1,000).: |
|
| Species Reactivity | Hepatitis C Virus |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | N/A |
|---|---|
| Alternative Names | Nonstructural Protein 5B |
| Tissue Specificity | Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382). It recognizes genotype 1 a and also 1b (albeit with lower affinity). It does not recognize genotype 2a. |
| Application Notes | Western Blot: (1:1,000).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
