Application
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using Nuclear Receptor NR4A1 (Phospho-Ser351) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | Nuclear Receptor NR4A1 (phospho Ser351) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NGFIB, GFRP1, HMR, NR4A1, NAK1 |
| Product description | Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.1) Nakai A., Mol. Endocrinol. 4:1438-1443(1990). |
| Immunogen | Nuclear Receptor NR4A1 (phospho Ser351) antibody was raised against a peptide sequence around phosphorylation site of Serine351 (L-P-S (p)-K-P) derived from Human Nuclear Receptor NR4A1. |
| Modification | p-Ser351 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NR4A1 |
|---|---|
| Alternative Names | NGFIB GFRP1 HMR NR4A1 NAK1 |
| Molecular Weight(MW) | 64 kDa |
| Tissue Specificity | The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351 |
| Entrez Gene | 3164 |
|---|---|
| Protein Accession | NP_002126.2 |
Application
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using Nuclear Receptor NR4A1 (Phospho-Ser351) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
