| Product Name | Progranulin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Proepithelin; PEPI; PC Cell-derived Growth Factor |
| Product description | Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. |
| Immunogen | Recombinant human progranulin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1, k |
| Host Species | Mouse |
| Tested Applications | ELISAIHCIPWB |
| ELISA: (direct or indirect: 1:2,000-1:5,000). Immunohistochemistry: (paraffin sections (1:100)). Immunoprecipitation: (1:50-1:1,000). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | GRN |
|---|---|
| Alternative Names | Proepithelin PEPI PC Cell-derived Growth Factor |
| Tissue Specificity | Recognizes human progranulin. Detects a band of ~90kDa by Western blot. |
| Entrez Gene | 2896 |
|---|---|
| Protein Accession | NP_002078.1 |
| Application Notes | ELISA: (direct or indirect: 1:2,000-1:5,000). Immunohistochemistry: (paraffin sections (1:100)). Immunoprecipitation: (1:50-1:1,000). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives. |
