| Product Name | PTRF 1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1, |
| Product description | Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.1) Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132(1):23-4 |
| Immunogen | A synthetic peptide corresponding to the C terminal region. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ELISA, Western (immuno) blotting, Immunostaining (in testing): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PTRF |
|---|---|
| Alternative Names | 2310075E07Rik AW546441 Cavin MGC118550 Cavin 1 CAVIN1 CGL4 FKSG13 FLJ90031 OTTMUSP00000002049 polymerase I and transcript release factor RNA polymerase I and transcript release factor RP23-279L23.6 TTF I interacting 12 CAVIN cavin-1 |
| Application Notes | ELISA, Western (immuno) blotting, Immunostaining (in testing): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
