Application
Immunohistochemistry staining of TNFRSF11B in heart formlin-fixed paraffin-embedded) tissue using TNFRSF11B monoclonal Antibody.Application
Immunohistochemistry staining of TNFRSF11B in liver formlin-fixed paraffin-embedded) using TNFRSF11B monoclonal Antibody.| Product Name | TNFRSF11B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFRSF11B, OCIF, OPG, Osteoprotegerin, TR1 |
| Product description | Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor (TNFR) superfamily. As the name implies, it protects bone. Unlike other TNFRs it lacks a transmembrane domain and lacks any apparent cell associated signals. OPG consists of 401 amino acid with molecular mass of approximately 55 kD as a monomer and 110 kD as a disulfide-linked dimer. High levels of OPG mRNA has been detected in lung, heart, kidney, and placenta1. Recombinant OPG blocks osteoclastogenesis in vitro and increases bone density in vivo. Targeted deletion of OPG in mice results in severe early-onset of osteoporosity. These mice also exhibit increase in vascular calcification in the aorta and renal arteries suggesting that it may also play a role in degenerative arterial disease. |
| Immunogen | A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human OPG. The specificity was tested on recombinant OPG by western blot analysis. Percent identity by BLAST analysis: Human, Gibbon (100%); Monkey (94%); Marmoset, Panda, Dog, Ho ... |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| TNFRSF11B antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | GibbonHuman |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | TNFRSF11B |
|---|---|
| Alternative Names | TNFRSF11B OCIF OPG Osteoprotegerin TR1 |
| Tissue Specificity | The Osteoprotegerin antibody, clone 98A1071, detects all forms of Osteoprotegerin including monomeric, dimeric and Osteoprotegerin bound to RANKL (Vandooren, 2008) as well as Osteoprotegerin bound to TRAIL (Sandra, 2006). |
Application
Immunohistochemistry staining of TNFRSF11B in heart formlin-fixed paraffin-embedded) tissue using TNFRSF11B monoclonal Antibody.
Application
Immunohistochemistry staining of TNFRSF11B in liver formlin-fixed paraffin-embedded) using TNFRSF11B monoclonal Antibody.| Application Notes | TNFRSF11B antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | TNFRSF11B antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.2% gelatin, 0.05% sodium azide. |
