Application
Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | Trk A (phospho Tyr680/681) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth, TRK, Trk-A |
| Product description | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.1) Liu HY, et al. (2005) J Biol Chem 280, 19461-71 |
| Immunogen | Trk A (phospho Tyr680/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y (p)-Y (p)-R-V) derived from Human Trk A. |
| Modification | p-Tyr680/681 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NTRK1 |
|---|---|
| Alternative Names | High affinity nerve growth factor receptor precursor NTRK1 Slow nerve growth TRK Trk-A |
| Molecular Weight(MW) | 87 kDa |
| Tissue Specificity | The antibody detects endogenous level of Trk A only when phosphorylated at tyrosine 680/tyrosine 681. |
| Entrez Gene | 4914 |
|---|---|
| Protein Accession | NP_001007793.1 |
Application
Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
