Application
Western blot analysis of lysed extracts from Rat and Mouse brain tissue using TrkA (Phospho-Ser791).Application
Immunofluorescence staining of methanol-fixed HeLa cells using TrkA (Phospho-Ser791).| Product Name | TrkA (phospho Ser791) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, MGF, SCF, High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK1 transforming tyrosine kinase protein |
| Product description | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.1) Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43): 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30): 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33): 24175-84 |
| Immunogen | TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA. |
| Modification | p-Ser791 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IFWB |
| Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NTRK1 |
|---|---|
| Alternative Names | MTC TRK TRK1 TRKA Trk-A p140-TrkA MGF SCF High affinity nerve growth factor receptor precursor NTRK1 Slow nerve growth factor receptor TRK1 transforming tyrosine kinase protein |
| Molecular Weight(MW) | 140 kDa |
| Tissue Specificity | This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791. |
| Entrez Gene | 4914 |
|---|---|
| Protein Accession | NP_001007793.1 |
Application
Western blot analysis of lysed extracts from Rat and Mouse brain tissue using TrkA (Phospho-Ser791).
Application
Immunofluorescence staining of methanol-fixed HeLa cells using TrkA (Phospho-Ser791).| Application Notes | Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
