Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | Trk A (phospho Tyr757) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRKA, TRK, NTRK1, p140-TrkA |
| Product description | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.1) Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989). |
| Immunogen | Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p)-A-I) derived from Human Trk A. |
| Modification | p-Tyr757 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NTRK1 |
|---|---|
| Alternative Names | TRKA TRK NTRK1 p140-TrkA |
| Molecular Weight(MW) | 87 kDa |
| Tissue Specificity | The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757. |
| Entrez Gene | 4914 |
|---|---|
| Protein Accession | NP_002520.2 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
