y raised against amino acids
569-726 of Gephyrin of rat origin
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
IHCWB
WB:1:100-1:1000 IHC:1:50-1:500
Species Reactivity
HumanMouseRat
Concentration
0.1mg/ml
Purification
Affinity purified
Target Information
Gene Symbol
GPHN
Gene Synonyms
GPH GEPH HKPX1 GPHRYN MOCODC
Gene Full Name
gephyrin
Gene Summary
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]
Molecular Weight(MW)
93 kDa
Application
WB
Western blot analysis of Gephyrin expression in rat brain tissue extracts.
IHC
Immunoperoxidase staining of rat cerebellar tissue fixed in formalin and embedded in paraffin reveals cytoplasmic staining.
Application Notes
WB:1:100-1:1000 IHC:1:50-1:500
Additional Information
Form
Liquid
Storage Instructions
Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Storage Buffer
Each vial contains 50 µg IgG1 light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.