| Gene Symbol |
CAMK2A
|
| Gene Synonyms |
CAMKA
MRD53
MRT63
CaMKIIalpha
CaMKIINalpha |
| Gene Full Name |
calcium/calmodulin dependent protein kinase II alpha |
| Gene Summary |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018] |
| Molecular Weight(MW) |
54kDa(observed band size:40kDa) |
| Cellular Localization |
Cytoplasm, Sarcoplasmic reticulum membrane, Cell membrane, Cell junction |
