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Mouse Monoclonal antibody to CAMK2A/CaMKII alpha

Catalog Number:OM647433
OM647433
Discount Price
OM647433-100ul
100ul
Product Profile
Product Name Mouse Monoclonal antibody to CAMK2A/CaMKII alpha
Antibody Type Primary Antibodies
Immunogen raised against partially purified CaM kinase II of rat origin.
Key Feature
Clonality Monoclonal
Isotype IgG1, k
Host Species Mouse
Tested Applications IHCWB
WB:1:100-1:1000
IHC:1:50-1:500
Species Reactivity HumanMouseRat
Concentration 0.1mg/ml
Purification Affinity purified
Target Information
Gene Symbol CAMK2A
Gene Synonyms CAMKA
MRD53
MRT63
CaMKIIalpha
CaMKIINalpha
Gene Full Name calcium/calmodulin dependent protein kinase II alpha
Gene Summary The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]
Molecular Weight(MW) 50 kDa
Cellular Localization Cell projection,Synapse.
Application

WB

CaMKIIα Antibody : CAMK2A/CaMKII alpha Antibody. Western blot analysis of CaMKIIα expression in human brain (A), mouse cerebellum (B) and human cerebral cortex (C) tissue extracts.

IHC

CaMKIIa : CAMK2A/CaMKII alpha Antibody. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and neuropil staining of granular layer.
Application Notes WB:1:100-1:1000
IHC:1:50-1:500
Additional Information
Form Liquid
Storage Instructions Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Storage Buffer Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
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