This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Alternative Names
5'-Tyr-DNA phosphodiesterase 5'-tyrosyl-DNA phosphodiesterase EAP2 epididymis secretory sperm binding protein ETS1-associated protein 2 ETS1-associated protein II MGC111021 MGC9099 RP1-30M3.3 Traf and Tnf receptor associated protein TRAF and TNF receptor-associated protein tyr-DNA phosphodiesterase 2 tyrosyl-RNA phosphodiesterase VPg unlinkase