This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Alternative Names
78 kDa glucose-regulated protein 94 kDa glucose-regulated protein binding-immunoglobulin protein BiP chaperone endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 endoplasmic reticulum resident protein 99 endoplasmic reticulum transmembrane protein precursor Endoplasmin endothelial cell (HBMEC) glycoprotein epididymis luminal protein 35 epididymis secretory sperm binding protein Li 125m epididymis secretory sperm binding protein Li 89n ER lumen protein retaining receptor 1 glucose regulated protein 78 kDa glucose-regulated protein glucose-regulated protein (grp78) glucose-regulated protein 78 glucose-regulated protein 78kDa GRP-78 GRP-94 GRP94 heat shock 70 kDa protein 5 heat shock 70kD protein 5 heat shock 70kD protein 5 (glucose-regulated protein 78kD) heat shock 70kDa protein 5 (glucose-regulated protein) heat shock 70kDa protein 5 (glucose-regulated protein 78kDa) heat shock protein 5 heat shock protein 70 family protein 5 heat shock protein 90 kDa beta member 1 heat shock protein 90 beta (Grp94) member 1 heat shock protein 90 beta member 1 heat shock protein 90kDa beta (Grp94) member 1 heat shock protein 90kDa beta family member 1 heat shock protein family A member 5 heat shock protein family C member 4 HSP70 family protein 5 immunoglobulin heavy chain binding protein immunoglobulin heavy chain-binding protein KDEL KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 KDEL (Lys-Asp-Glu-Leu) receptor KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 KDEL receptor 1 Lys-Asp-Glu-Leu polymorphic tumor rejection antigen 1 polymorphic tumor rejection antigen precursor preimmunoglobulin heavy chain binding protein putative MAPK-activating protein PM23 RP23-446N16.1 steroidogenesis-activator polypeptide stress-inducible tumor rejection antigen gp96 transforming growth factor alpha regulated gene 2 tumor rejection antigen (gp96) 1 tumor rejection antigen 1 tumor rejection antigen gp96 XAP-1 antigen