| Product Name | Anti-Phospho-IREB1 (Ser138) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser138 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ACO1 |
|---|---|
| Gene Synonyms | IRP1 ACONS HEL60 IREB1 IREBP IREBP1 |
| Gene Full Name | aconitase 1 |
| Gene Summary | The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014] |
| Alternative Names | ACO 1 ACO1 ACOC_HUMAN Aconitase 1 soluble Aconitase Aconitase1 Aconitate hydratase ACONS Citrate hydro lyase Citrate hydro-lyase Cytoplasmic aconitate hydratase Ferritin repressor protein IRE BP 1 IRE-BP 1 IREB 1 IREB1 IREBP IREBP1 Iron regulatory protein 1 Iron responsive element binding protein 1 Iron-responsive element-binding protein 1 IRP 1 IRP1 OTTHUMP00000045233 |
| Molecular Weight(MW) | 98 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | P21399 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
