All products Antibodies Anti-Cyclin D1 antibody

Anti-Cyclin D1 antibody

Catalog Number：OM641722

  • Western blot analysis using Cyclin D1 antibody against Hep G2 (1), T24 (2), Hela (3) cell lysate.

  • Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using Cyclin D1 antibody with DAB staining

Product Profile

Product Name Anti-Cyclin D1 antibody
Antibody Type Primary Antibodies
Immunogen 
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAIHCWB
IHC:1:50~1:200
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml
Purification Protein A

Target Information

Gene Symbol CCND1
Gene Synonyms
BCL1
PRAD1
U21B31
D11S287E
Gene Full Name cyclin D1
Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
Molecular Weight(MW) 34 kDa（Observed: 40 kDa）
Cellular Localization Nucleus

Application

  • WB

    Western blot analysis using Cyclin D1 antibody against Hep G2 (1), T24 (2), Hela (3) cell lysate.

  • IHC

    Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using Cyclin D1 antibody with DAB staining

Application Notes
IHC:1:50~1:200
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM641722
  • Price: $336.00
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  • Lead time: 4~6 Week

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