Western blot analysis using HSP27 antibody against Hela (1), A549 (2), HepG2 (3), K562 (4) cell lysate.
Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using HSP27 antibody with DAB staining.
Immunofluorescence analysis of A549 cells using HSP27 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Molecular Weight(MW)
23 kDa
Source
Rabbit
Cellular Localization
Cytoplasm, Cytoskeleton, Nucleus
Application
WB
Western blot analysis using HSP27 antibody against Hela (1), A549 (2), HepG2 (3), K562 (4) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using HSP27 antibody with DAB staining.
ICC/IF
Immunofluorescence analysis of A549 cells using HSP27 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
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