All products Antibodies HSPB1 Antibody

HSPB1 Antibody

Catalog Number：OM281440

  • Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with HSPB1 Antibody (S82) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

  • Western blot analysis of HSPB1 using rabbit polyclonal HSPB1 Antibody (S82) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HSPB1 gene (Lane 2).

Product Profile

Product Name HSPB1 Antibody
Antibody Type Primary Antibodies
Product description 
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.1) Wano, C., et al., Exp. Cell Res. 298(2):584-592 (2004).
Immunogen 
This HSPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from human HSPB1.

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

IHC-PWB
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol HSPB1
Alternative Names
Heat shock protein beta-1
HspB1
28 kDa heat shock protein
Estrogen-regulated 24 kDa protein
Heat shock 27 kDa protein
HSP 27
Stress-responsive protein 27
SRP27
HSPB1
HSP27
HSP28
Molecular Weight(MW) 23 kDa

Database Links

Entrez Gene 3315
Protein Accession P04792

Application

  • Application

    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with HSPB1 Antibody (S82) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

  • Application

    Western blot analysis of HSPB1 using rabbit polyclonal HSPB1 Antibody (S82) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HSPB1 gene (Lane 2).

Application Notes
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM281440
  • Price: $336.00
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